产品货号：
Z17399
中文名称：
HDAC8抗体
英文名称：
Anti-HDAC8 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-HDAC8 Antibody |
| 指标别名 | HD8;HDAC8;HDACL1;histone deacetylase 8;RPD3 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | HDAC8 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human HDAC8(18-33aa YIYSPEYVSMCDSLAK),different from the related mouse and rat sequences by two amino acids. |
| 实际分子量 | 42KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | HDAC8,Histone deacetylase 8,is an enzyme that in humans is encoded by the HDAC8 gene,and is biologically involved in skull morphogenesis and metabolic control of the ERR-alpha/PGC1-alpha transcriptional complex.Sequence analysis predicted that the 377-amino acid HDAC8 protein contains the 9 conserved HDAC blocks that are presumably important for catalytic function.HDAC8 shares 54% sequence similarity with HDAC1 and HDAC2 and 39% similarity with HDAC3,making it a class I HDAC.Histones play a critical role in transcriptional regulation,cell cycle progression,and developmental events.Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family.It has histone deacetylase activity and represses transcription when tethered to a promoter. |
| Uniprot ID | Q9BY41 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | histone deacetylase 8 |
| 蛋白名全称 | Histone deacetylase 8(HD8) |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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